Aims Organic and Bio-organic Chemistry
Upon completion of the subject, the student is able to:
- Describe alkene and alkyne reactions
- Describe substitution reactions and elimination reactions of alkyl halides
- Describe reactions of alcohols, amines, ethers, epoxides and organometallic compounds
- Understands the reactivity of radicals
- Describe and understands how carbonyl compounds react (nucleophilic acyl substitution; reactions of aldehydes and ketones; reactions of carbon)
- Describe reactions of substituted benzenes
- Describe acid-base behaviour of amines and the reactivity of heterocyclic compounds.
- Describe and understands how functional groups react in biomolecules
- Understands catalysis in organic chemistry and enzymes
Aims Lab Course
- Both theoretical and practical preparation (including safety aspects) of an experiment to be performed according to a known procedure. Another important component is planning of the various elements.
- Performing a (bio-)organic experiment independently.
- Analysing and characterising a synthesised compound.
- Processing the results in a report.
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Content Organic and Bio-organic Chemistry
The objective of this subject is to provide a broad and practical understanding of the reactivity of organic compounds based on various functional
groups, in particular the functionalities at play in biomolecules such as proteins and nucleic acids.
This course builds on the Organic Chemistry segment in Quarter 1 of the Chemical Science & Engineering bachelor.
Subject Content
- Reactions of alkenes and alkynes (repetition from CSE M1).
- Substitution reactions and elimination reactions of alkyl halides (repetition from CSE M1).
- Aromaticity. Benzene and substituted benzene reactions (repetition from CSE M1).
- Radicals.
- Carbonyl compounds I. Nucleophilic acyl substitution.
- Carbonyl compounds II. Aldehyde and ketone reactions.
- Carbonyl compounds III. Carbon reactions.
- Reactions of alcohols, amines, ethers and epoxides. Organometallic compounds.
- Amines, Heterocyclic compounds.
- Chemistry of sugars
- Chemistry of amino acids, peptides and proteins
- Catalysis
- Chemistry of nucleic acids.
Approximately 25% of the aforementioned subject matter has already been addressed in Organic Chemistry in Quarter 1. This subject matter will now be refreshed and expanded upon.
Teaching methods: lectures, tutorial and online tools. Given the limited number of lecture hours, it is not possible to discuss all the subject matter in its entirety and in detail during the lecture. It is highly recommended to try the assignments at home in advance so that any problems that may have emerged can be addressed during the tutorial.
Content Lab Course
The practical consists of three individual assignments aligned with the lecture.
It involves a condensation reaction (carbonyl compounds), an electrophilic aromatic substitution reaction and an enzymatically catalysed
reaction.
Each assignment involves the synthesis and purification of a compound as well as analysis of the structure and purity of the product obtained using one or more of the following techniques: 1H NMR and IR spectroscopy, UV-Vis spectrophotometry and mass spectrometry. Procedures
and a brief theoretical background of the synthesis can be found on Canvas.
The first practical day begins with a brief (fire) safety instruction. More elaborate instructions and general laboratory technology instructions have already been provided in Q1.
Practical work preparations entail studying (understanding) and elaborating the instructions, completing the hazardous substances information chart and requesting chemicals (and glassware). All of this must be discussed in a preliminary meeting with the assistant.
The reporting element comprises the drafting of a report, using a standard form, of two experiments and a report of the second or third experiment. In addition to the theoretical background, the report must pay enough attention to evaluation of the practical work, both in terms of synthesis and analysis.
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