Kies de Nederlandse taal
Course module: 202001436
Biofluid Dynamics: Theory and Analysis
Course infoSchedule
Course module202001436
Credits (ECTS)5
Course typeCourse
Language of instructionEnglish
Contact persondr. K. Jain
Lecturer R. Hagmeijer
dr. K. Jain
Contactperson for the course
dr. K. Jain
Academic year2022
Starting block
Application procedureYou apply via OSIRIS Student
Registration using OSIRISYes
After the course, the students should be able to:
  • Understand the basic physiology of circulation
  • describe biofluids from mathematical and physical perspective
  • Understand the arterial and the venous system
  • Understand fluid dynamics of the ventricular system
  • Describe the microcirculation (capillaries and lymphatics) and the non-continuum nature of flows in the microvasculature
  • Understand how experimental analyses of bioflows are performed using imaging and phantom models
  • Have a basic understanding of the considerations one needs to make to simulate such flows
  • Understand aspects of high performance computing

  1. Physiology of Circulation
  2. Physics and mathematics of physiologic flows
  3. Flow in the arterial system
  4. Flow in the venous system
  5. The ventricular system
  6. Pulmonary Flows
  7. The lymphatic system
  8. Microcirculation
  9. Computational Modeling
  10. Experimental Analyses

The course will start with a discussion on the basic physiology of circulation in the body. In particular the cardiac system and its association with whole body circulation will be discussed from a purely Biological standpoint. We will then start taking an Engineering view towards the circulation. The Physical principles that drive flow in the body and the mathematical equations that describe some of these flows on a continuum level will be discussed. Concepts related to flow in the arteries will be discussed with a brief introduction to anatomy where needed.  Then, the cerebrospinal fluid, which is one of the most misunderstood biofluid will be described and the oscillatory nature of the flow will be studied in depth to understand the spatial and temporal complexity of such flows. This will be followed by respiratory flows and lymphatic system. The knowledge gained from these topics will pave the path to study microcirculation where non-continuum nature of the flow in such vessels will be of emphasis. Subsequently various forms of experiments to study physiologic flows will be introduced including laboratory experiments on phantom models as well as in vivo studies on animal models, followed by the ethical concerns in such studies. The penultimate part of the course will introduce concepts like lumped parameter model, reduced order models and fully resolved 3D computational fluid dynamics (CFD). Finally, medical imaging, image processing using artificial intelligence and concepts of high performance computing (HPC) will be introduced.

Assumed previous knowledge
1. Fluid Mechanics 1 - 202000138
2. Fluid Physics - 202000705
Participating study
Master Mechanical Engineering
Required materials
Course material
Biomechanics Circulation by YC Fung ISBN 978-1-4757-2696-1
Course material
Lecture slides, notes and other material
Recommended materials
Course material
Biofluid Dynamics by Clement Kleinstreuer ISBN 978-0849322211
Course material
Biofluid Mechanics Analysis and Applications by James B. Grotberg ISBN: 9781107003118
Instructional modes
Presence dutyYes

Presence dutyYes

Assignment(s) and oral exam

Kies de Nederlandse taal