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Cursus: 202001436
Biofluid Dynamics: Theory and Analysis
Cursus informatieRooster
Studiepunten (ECTS)5
Contactpersoondr. K. Jain
Docent R. Hagmeijer
dr. K. Jain
Contactpersoon van de cursus
dr. K. Jain
AanmeldingsprocedureZelf aanmelden via OSIRIS Student
Inschrijven via OSIRISJa
After the course, the students should be able to:
  • Understand the basic physiology of circulation
  • describe bioflows from mathematical and physical perspective
  • Understand the arterial and the venous system
  • Understand flow dynamics of ventricular, pulmonary and lymphatic flows
  • Describe the microcirculation (capillaries etc) and the non-continuum nature of flows in the microvasculature
  • Understand how experimental analyses of bioflows are performed using imaging, phantom models etc
  • Have a basic understanding of the considerations one needs to make to simulate such flows
  • Understand aspects of various high performance computing paradigms, imaging and basic image analysis using artificial intelligence
  1. Physiology of Circulation
  2. Physics and mathematics of physiologic flows
  3. Flow in the arterial system
  4. Flow in the venous system
  5. The ventricular system
  6. Pulmonary Flows
  7. The lymphatic system
  8. Microcirculation
  9. Experimental analyses
  10. Computational Modeling
The course will start with a discussion on the basic physiology of circulation in the body. In particular the cardiac system and its association with whole body circulation will be discussed from a purely Biological standpoint. We will then start taking an Engineering view towards the circulation. The Physical principles that drive flow in the body and the mathematical equations that describe some of these flows on a continuum level will be discussed. Concepts related to flow in the arteries will be discussed with a brief introduction to anatomy where needed.  Then, the cerebrospinal fluid, which is one of the most misunderstood biofluid will be described and the oscillatory nature of the flow will be studied in depth to understand the spatial and temporal complexity of such flows. This will be followed by respiratory flows and lymphatic system. The knowledge gained from these topics will pave the path to study microcirculation where non-continuum nature of the flow in such vessels will be of emphasis. Subsequently various forms of experiments to study physiologic flows will be introduced including laboratory experiments on phantom models as well as in vivo studies on animal models, followed by the ethical concerns in such studies. The penultimate part of the course will introduce concepts like lumped parameter model, reduced order models and fully resolved 3D computational fluid dynamics (CFD). Finally, medical imaging, image processing using artificial intelligence and concepts of high performance computing (HPC) will be introduced.
1. Fluid Mechanics 1 - 202000138
2. Fluid Physics - 202000705
Participating study
Master Mechanical Engineering
Verplicht materiaal
Course material
Biomechanics Circulation by YC Fung ISBN 978-1-4757-2696-1
Course material
Lecture slides, notes and other material
Aanbevolen materiaal
Course material
Biofluid Dynamics by Clement Kleinstreuer ISBN 978-0849322211


Assignment(s) and oral exam

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