
After the course, the students should be able to:
 Understand the basic physiology of circulation
 describe bioflows from mathematical and physical perspective
 Understand the arterial and the venous system
 Understand flow dynamics of ventricular, pulmonary and lymphatic flows
 Describe the microcirculation (capillaries etc) and the noncontinuum nature of flows in the microvasculature
 Understand how experimental analyses of bioflows are performed using imaging, phantom models etc
 Have a basic understanding of the considerations one needs to make to simulate such flows
 Understand aspects of various high performance computing paradigms, imaging and basic image analysis using artificial intelligence


 Physiology of Circulation
 Physics and mathematics of physiologic flows
 Flow in the arterial system
 Flow in the venous system
 The ventricular system
 Pulmonary Flows
 The lymphatic system
 Microcirculation
 Experimental analyses
 Computational Modeling
The course will start with a discussion on the basic physiology of circulation in the body. In particular the cardiac system and its association with whole body circulation will be discussed from a purely Biological standpoint. We will then start taking an Engineering view towards the circulation. The Physical principles that drive flow in the body and the mathematical equations that describe some of these flows on a continuum level will be discussed. Concepts related to flow in the arteries will be discussed with a brief introduction to anatomy where needed. Then, the cerebrospinal fluid, which is one of the most misunderstood biofluid will be described and the oscillatory nature of the flow will be studied in depth to understand the spatial and temporal complexity of such flows. This will be followed by respiratory flows and lymphatic system. The knowledge gained from these topics will pave the path to study microcirculation where noncontinuum nature of the flow in such vessels will be of emphasis. Subsequently various forms of experiments to study physiologic flows will be introduced including laboratory experiments on phantom models as well as in vivo studies on animal models, followed by the ethical concerns in such studies. The penultimate part of the course will introduce concepts like lumped parameter model, reduced order models and fully resolved 3D computational fluid dynamics (CFD). Finally, medical imaging, image processing using artificial intelligence and concepts of high performance computing (HPC) will be introduced.




 VoorkennisMandatory: 1. Fluid Mechanics 1  202000138 OR 2. Fluid Physics  202000705 
Master Mechanical Engineering 
  Verplicht materiaalCourse materialBiomechanics Circulation by YC Fung ISBN 9781475726961 
 Course materialLecture slides, notes and other material 

 Aanbevolen materiaalCourse materialBiofluid Dynamics by Clement Kleinstreuer ISBN 9780849322211 

 WerkvormenLectureAanwezigheidsplicht   Ja 
 TutorialAanwezigheidsplicht   Ja 

 ToetsenAssignment(s) and oral exam


 