The human body is a complex system in which, among others, transport phenomena (mass, impulse, energy), thermodynamics and chemical reactions play a critical role. Special mechanisms are in place, dedicated to regulating the distribution of molecules between cells and tissues.|
Many organs, such as the liver, lungs, and kidneys, are capable of rapidly exchanging molecules between the blood and tissues. Besides, various biological levels of organisation (e.g., density of capillaries) can be related to the transport of molecules from their source to a destination in the body. In fact, disturbances in transport processes contribute to disorders such as atherosclerosis, cancer, and kidney disease. Therefore, proper knowledge and understanding of transport phenomena is essential for Biomedical Engineers. These would allow them to study the behaviour of the human body and develop novel therapies or technological advancements to combat disorders and cure diseases. Therefore, important knowledge on transport phenomena, thermodynamics and reaction kinetics are offered in this module.
The module aims to provide knowledge on transport phenomena thermodynamics and reaction kinetics via the following courses:
- Momentum, mass, and transfer of energy (Biophysical Transport Phenomena & Introduction Transport Phenomena course).
- Thermodynamics (Physical Chemistry of Life Sciences course).
- Kinetics of chemical reactions (Reaction Kinetics course).
- Predicting and modelling (Modelling and Analysis of Dynamic Systems course).
The lectures (hoorcollege: HC) and tutorials (werkcollege: WC) will discuss the basic principles of the processes that take place in the human body and how they could be understood and modelled.
During this module, the principal laws of thermodynamics for the life sciences are introduced. They are essential to understand fundamental principles such as conservation of energy and heat and mass transfer. Mass and heat transfer is discussed in more detail using basic transport mechanisms such as diffusion and convection. They influence various bodily functions such as: thermoregulation (body temperature and heat regulation), the respiratory system (lungs and oxygenation), blood purification (kidneys and metabolism) and the cardiovascular system (heart, veins, and transport of oxygen).
The project “Project Modelling of an Artificial Kidney” consists of HC, tutorials, and a laboratory practical:
- Clinical and engineering aspects of an artificial kidney device (lectures Prof. Stamatialis).
- Modelling of transport phenomena in an artificial kidney device (MADS).
- Laboratory practical of artificial kidney.
During the project, you will develop models consisting of a mathematical-physical description using algebraic and dynamic equations. A series of lectures would teach you the mathematical background needed. During the practical, you will identify and explore important parameters which influence blood filtration using an artificial kidney. The obtained results must be used to compare to the modelling results.
The project is carried out in groups of appr. 8 students. You will need to prepare two deliverables (by using mathematical models, analyses, and simulations) and in addition a laboratory practical report. All components must be thoroughly documented by each group.
An individual multiple-choice (MC) exam will take place to evaluate your knowledge and understanding of the project at the end of the module. The final grade of the module is a weighted average of the project grade and grades for the supporting courses as described later in this manual.
|Bachelor Biomedical Engineering||Required materials|
|e‐books die via de Universiteitsbibliotheek beschikbaar zijn en zullen worden geplaatst op Canvas|
|Physical Chemistry for the Life Sciences, P. Atkins & J. de Paula, ISBN: 978-0-19-956428-6|
|Modelling and Analysis of Dynamical Systems|
|Physical Chemistry: Principles and Applications in Biological Sciences, 5th Edition, augustus 2016. LET OP: Het boek niet aangeschaffen, omdat er slechts 1 hoofdstuk uit wordt behandeld|
|Self study with assistance|
|Self study without assistance|
|Project Modelling an Artificial kidney|
|Biophysical Transport Phenomena|
|Introduction to Transport Phenomena|
|Physical Chemistry & Thermodynamics|
|Modelling and Analysis of Dynamic Systems|