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Course module: 201900088
201900088
Applied Cell Biology
Course infoSchedule
Course module201900088
Credits (ECTS)5
Course typeCourse
Language of instructionEnglish
Contact persondr.ing. J.N. Post
E-mailj.n.post@utwente.nl
Lecturer(s)
Lecturer
prof.dr. P.C.J.J. Passier
Lecturer
J.R.M. Plass
Contactperson for the course
dr.ing. J.N. Post
Lecturer
dr.ing. J.N. Post
Lecturer
K. Vermeul
Academic year2020
Starting block
1B
Application procedure-
Registration using OSIRISYes
Aims
The overall goal of the course Applied Cell Biology is to understand and apply cell biological processes to allow solving problems in biology inspired Biomedical Engineering and in Regenerative Medicine.
 
Content
a) Theoretical and technical lectures on Applied Cell Biology; 
b) In-depth analysis and oral presentation of a research paper on Applied Cell Biology
c) Design experiments based on a hypothesis, perform experiment and verbally report, including poster presentation.
d) Experimental design will be guided by computational model of cellular communication network. The students will generate dynamic models in ANIMO, a software tool developed in-house.
 
Learning goals:
a) Get acquainted with terminology used in Applied Cell Biology;
b) Understanding the principles of cellular communication at advanced level.
c) Use the knowledge of cell signaling for the development of typical biomedical engineering strategies for controlling cell behavior.
c) Understand how genetic information flows and how one can control it to steer cell behavior;
d) Understand how tissues develop and are maintained throughout the life of an organism and use this knowledge for solving challenges in development of organs-on-chip;
e) Understand the road from hypothesis to conclusion and techniques used to test and confirm/discard a hypothesis;
f) Capable of selecting the most appropriate molecular and/or cell biological techniques for testing an hypothesis;
g) Perform a cell biology experiment, analyze data using a computational model and present data orally in poster format.
 
Note: this course is compulsory for students enrolling for the course Tissue Engineering
 
Assessment:
The assessment consists of 4 elements:

1. Lab work and lab book: 10%
2. Oral presentation of research paper: 20%
3. Poster presentation of Practical work: 30%
4. Written exam: 40%

Please note: the content of this course has changed from the course 2018-2019. The thesis organ-on-chip has moved to another course, and the new ACB course will have more labwork and focus on designing and performing experiments.
The previous course code was: 201400330
 
Assumed previous knowledge
The bachelor BMT module M11, Modules M2 and M5 are mandatory. For (inter)national students and students that did not do a BMT Bachelor the master course “Introduction in Bioengineering Technologies” given in Q1 of the BME master is compulsory.

Note: this course is compulsory for students enrolling for the course Tissue Engineering
Participating study
Master Biomedical Engineering
Required materials
Course material
Scientific papers Available online.
Course material
Course manual Available on Canvas
Software
https://fmt.ewi.utwente.nl/tools/animo/
Recommended materials
Book
van Blitterswijk, C.; Thomsen, P.; Hubbell, J.; Cancedda, R.; de Bruijn, J.; Lindahl, A.; Sohier, J.; Williams, D.F., Tissue Engineering (Academic Press Series in Biomedical Engineering); Eds. 2nd ed. Academic Press, 2014 (available as E-book at the
Book
Alberts, B.; Johnson, A.; Lewis, J.; Raff, M.; Roberts, K.; Walter, P. Garland Science, Essential Cell Biology 4th edition. 4th edition is also still allowed in 2020 and 2021
Instructional modes
Lecture
Presence dutyYes

Practical
Presence dutyYes

Self study without assistance

Workshop
Presence dutyYes

Tests
Assignments

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