After following the course the student can...
- Explain different sample preparation/separation techniques and their field of application (i.e. type of biomarkers, required purity, field of application).
- Explain different detection techniques and their field of application (i.e. type of biomarkers, required sensitivity, field of application).
- Explain the benefits in the use of microfluidic devices in different steps of in-vitro diagnostic tests.
- Name and explain new developments in the field of IVD and understand the advantages of the new developments compared to classical approaches
- Analyze a typical analytical process for IVD, explain the meaning and purpose of every step, and justify the choices made for each step.
- Describe in own words/explain/summarize IVD technology in a short and concise manner using different forms of input (books, articles, internet), identify the shortcomings of existing or proposed concepts and propose alternative concepts or improvements.
- Propose an analytical process for the detection of targeted biomarkers and design an associated IVD protocol and device.
- Explain and evaluate critically scientific papers with respect to a proposed in-vitro analytic process.
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In vitro diagnostics (IVD) is the analysis of bodily fluids and tissue samples for the purpose of medical diagnostics.
Main aims of the course:
- To understand the requirements an IVD device has to fulfil
- To understand the processes and concepts employed in existing IVD devices
- To apply this understanding to critically assess recent developments and proposed concepts for targeted biomarkers and/or diseases.
Lecture: After an introduction on the purpose of IVD devices and the requirements they have to fulfil, the lectures will focus on the (bio)-chemical and physical processes and technical concepts employed in these devices:
- Sample preparation techniques
- enrichment/purification/separation
- amplification
- labelling
- label free
- fluorescence based
- electrochemical/electrical
- Microfluidics for IVD
- Point-of-care diagnostics
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Students will work in groups to prepare a summary a self-chosen topic (challenge) within the context of in -vitro diagnostics in a presentation. They will develop their own concept to address this challenge and present their solution in a poster presentation.
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