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Course module: 201700040
201700040
In vitro diagnostics
Course infoSchedule
Course module201700040
Credits (ECTS)5
Course typeCourse
Language of instructionEnglish
Contact personprof.dr.ir. S. le Gac
E-mails.legac@utwente.nl
Lecturer(s)
Contactperson for the course
prof.dr.ir. S. le Gac
Lecturer
prof.dr.ir. S. le Gac
Lecturer
prof.dr. A. Kocer
Lecturer
dr.ir. W. Olthuis
Lecturer
prof.dr. L.W.M.M. Terstappen
Academic year2020
Starting block
1A
Application procedureYou apply via OSIRIS Student
Registration using OSIRISYes
Aims
After following the course the student can...
•         Explain different sample preparation/separation techniques and their field of application (i.e. type of biomarkers, required purity, field of application).
•         Explain different detection techniques and their field of application (i.e. type of biomarkers, required sensitivity, field of application).
•         Explain the benefits in the use of microfluidic devices in different steps of in-vitro diagnostic tests.
•         Name and explain new developments in the field of IVD and understand the advantages of the new developments compared to classical approaches
•         Analyze a typical analytical process for IVD, explain the meaning and purpose of every step, and justify the choices made for each step.
•         Describe in own words/explain/summarize IVD technology in a short and concise manner using different forms of input (books, articles, internet), identify the shortcomings of existing or proposed concepts and propose alternative concepts or improvements.
•         Propose an analytical process for the detection of targeted biomarkers and design an associated IVD protocol and device.
•         Explain and evaluate critically scientific papers with respect to a proposed in-vitro analytic process.
Content
In vitro diagnostics (IVD) is the analysis of bodily fluids and tissue samples for the purpose of medical diagnostics.
Main aims of the course:
  • To understand the requirements an IVD device has to fulfil
  • To understand the processes and concepts employed in existing IVD devices
  • To apply this understanding to critically assess recent developments and proposed concepts for targeted biomarkers and/or diseases.
 
Lecture: After an introduction on the purpose of IVD devices and the requirements they have to fulfil, the lectures will focus on the (bio)-chemical and physical processes and technical concepts employed in these devices:
• Sample preparation techniques 
  - enrichment/purification/separation 
  - amplification 
  - labelling
• Detection techniques: 
  - label free 
  - fluorescence based 
  - electrochemical/electrical
• Microfluidics for IVD
• Point-of-care diagnostics
 
Assignments:
Students will work in groups to prepare a summary a self-chosen topic (challenge) within the context of in -vitro diagnostics in a presentation. They will develop their own concept to address this challenge and present their solution in a poster presentation.
Assumed previous knowledge
Mandatory: Entry requirements for BME. Recommended:\par Fundamental knowledge and concepts from cell biology, biochemistry, chemistry, physics: - Biology/Biochemistry: Cell structure, organelles, DNA, RNA, proteins, enzymes, antibodies; - Chemistry: fundamentals of inorganic and organic chemistry, standard techniques; - Physics: Fundamentals of optics, thermodynamics; - Math: Statistics
Participating study
Master Biomedical Engineering
Required materials
-
Recommended materials
-
Instructional modes
Lecture
Presence dutyYes

Presentation(s)
Presence dutyYes

Project supervised
Presence dutyYes

Remark
choose a topic, work on it more or less independently, and will discuss their progress and ideas about once a week
Tests
Written exam/Assignments/Presentations

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