Kies de Nederlandse taal
Course module: 201600273
Clinical Biotechnology
Course info
Course module201600273
Credits (ECTS)5
Course typeCourse
Language of instructionEnglish
Contact A.M. Leferink
dr. M.N.A. Bijman
Examiner A.M. Leferink
Contactperson for the course A.M. Leferink
Academic year2022
Starting block
Application procedure-
Registration using OSIRISYes
Cursusdoelen (Engels)
This course is set-up according the framework of Challenge Based Learning. Therefore, a great deal of self-steering is expected from the participants, both in defining the learning objectives as in the contents of the course.
The student will be encouraged to define a ‘challenge’ within the domain of healthcare and to explore a direction of potential solutions within the field of clinical biotechnology to overcome the challenge. The student will be geven the opportunity to define his/her own learning objectives regarding the field of clinical biotechnology as well as in the area of soft or academic skills and other competencies. To support the process of gaining knowlegde in the field of expertise, various topics will be discussed via multiple methods (journal club, seminars, workshops).
Students that have not been enrolled in the programs of Technische Medicine or Biomedical Engineering are requested to first contact the coordinator of the course before enrolment to check for eligibility.
For a successful finalization of the course at least the following learning objectives will have to be met.

1. The student is aware of important technological developments related to restoring the function of vital physiological processes and is able to apply this knowledge in clinical cases related to
  • personalized medicine and diagnostics.
  • organpreservation technology for transplantation surgery.
  • instructive biomaterials for regenerative medicine approaches.
2. The student is able to propose a plan for research, development or application of technology based on the state-of-the-art to advance clinical cases related to the fields previously mentioned in a presentation and/or short scientific report.

3. The student is able to outline and critically review literature on the state-of-the of regenerative biomedical technology and manages to clinically contextualize the content of these articles.

General (optional) objective

4. The student will be given the opportunity to develop (further) in critically reviewing literature and academic writing in the English language by writing essays about various topics.
Clinical Biotechnology will be focusing on both innovative aspects and fundamental knowledge in the field of (amongst others) biomaterials, cell biology and physiological processes. We will explore various fields of research and application such as:
Personalized medicine and diagnostics.
Can a patient or disease profile be set-up as such that the best fit treatment can be selected? Can advanced diagnostics tests be developed to provide us with more information on the status of the patient or the stage of disease progression?
Personalized medicine is an upcoming field with a high probability of relevance in healthcare both by increasing the quality of treatments as well as impacting economic aspects.
Orgaanpreservation technology for transplantationsurgery.
Organ transplantations are life-saving procedures. Yet, current organ preservation methodologies still shows shortcomings with respect to organ vitality. Sufficient organ nutrition and logistics remain a challenge. When we would be able to improve preservation and transport of transplantation organs, this will create and enormous improvement in the success of transplantation surgery. In this course we will learn about, and search for, approaches and technologies to increase the vitality of transplant organs.
Reconstructive medicine and instructive biomaterials.
Our body is not designed to perform endlessly at the activity level that we expect.
Tissue damage and aging results in an increasing need for smart biomaterials.
This need does not limit to artificial joints or orthopedic implants but also includes smart membranes for dialysis, heart valves, intravascular catheters and transcutaneous drug delivery systems. What can we do to create more instructive, smarter, safer, more effective and innovative materials and applications?
To support the three mentioned themes, several fundamental cell biological, physiological land biomaterial-related aspects will be highlighted in seminars involving a literature study and a discussion session. These sessions cover topics related to for example cells and stem cells, scaffolds and immune responses.
Challenge Presentation and report 40%
Challenge Learning objectives and Sel-assessment pass
Final exam Clinical Biotechnology Individual Oral exam 60% (>5.5)
Practical orthopaedics attendance and/or stakeholder interview
Assumed previous knowledge
BSc. Technische Geneeskunde óf BSc. Biomedische Technology.
Kennis van de fysiologie van het menselijk lichaam en van celbiologische processen is een pré.
Participating study
Master Technical Medicine
Participating study
Master Biomedical Engineering
Required materials
Recommended materials
Instructional modes


Self study without assistance

Presence dutyYes

Clinical Biotechnology

Kies de Nederlandse taal