Upon completion of this course, the student can:
1. Describe primary, secondary, tertiary and quaternary structures of protein; properties of the protein folding; and protein purification, identification and characterization methods.
2. Explain the basic principles of enzyme kinetics and catalysis.
3. Explain how information flows from DNA to protein i.e. describe DNA replication, repair and recombination mechanisms; mechanisms behind RNA and protein synthesis and processing including RNA transcription and splicing, and protein translation.
4. Describe mechanisms of transport, the role of different pumps and ion channels, and biochemistry behind the five primary senses (sight, smell, touch, taste and hearing).
5.Understand the difference between innate and adaptive immune system; and describe the concepts behind antigen recognition and presentation.
6. Discuss the general features of molecular motors that covert chemical energy into mechanical energy.
7. Describe the signal transduction circuits (molecular on-off switches) in biological systems.
8. Describe different metabolic pathways with which environmental energy (food) is converted into the cellular energy (ATP), and discuss which pathway is fuel efficient. Describe how different components i.e. fatty acids, glycogen and proteins are metabolized
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Biochemistry is the study of the chemistry of life processes. With this course, we aim to unravel with students the chemistry of life. Topics included are: Protein composition and structure, protein purification, identification and characterization methods; enzyme kinetics and catalysis; DNA, RNA and flow of genetic information; DNA replication, repair and recombination; RNA and protein synthesis; membrane channels and pumps; signal transduction pathways; sensory, immune and molecular motor systems; metabolic pathways including glycolysis, gluconeogenesis, citric acid cycle, oxidative phosphorylation, pentose phosphate; glycogen, fatty acid and protein metabolism.
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