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Molecular recognition is an essential phenomenon in living systems as well as in artificial ones. It describes the specific interaction between molecules, ranging from discrete complexes to large architectures. The course will discuss supramolecular systems going from basic molecular recognition (involving single, monovalent interactions), to systems with cooperativitye and/or multivalency, and finally to lage polyvalent systems. For all subclasses, molecular and biomolecular examples will be discussed as well as materials applications.
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Noncovalent interactions, development of supramolecular chemistry (incl. the Excel modeling of thermodynamec equilibria)
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Synthetic host-guest chemistry I: cation-binding hosts
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Synthetic host-guest chemistry II: binding of guests in solution
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Molecular recognition in biological systems, enzyme catalysis
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Sensor concepts and sensor devices
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Cooperativity: molecular and biomolecular (e.g. hemoglobin) examples
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Multivalency: effective molarity concept, cyclization, cell membrane recognition
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Polyvalent systems I: macromolecular assembly + supramolecular polymers
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Polyvalent systems II: coordination polymers, MOFs
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Polyvalent systems III: proteins an protein folding
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Polyvalent systems IV: virus assembly
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Polyvalent systems V: DNA + artificial DNA constructs
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Polyvalent systems VI: layer-by-layer assembly
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Polyvalent systems VII: supramolecular materials
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