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Course module: 193700020
193700020
AMM - Molecular and Biomolecular Chem. and Techn.
Course infoSchedule
Course module193700020
Credits (ECTS)5
Course typeCourse
Language of instructionEnglish
Contact personprof.dr.ir. J. Huskens
E-mailj.huskens@utwente.nl
Lecturer(s)
Lecturer
prof.dr. J.J.L.M. Cornelissen
Examiner
prof.dr.ir. J. Huskens
Contactperson for the course
prof.dr.ir. J. Huskens
Academic year2022
Starting block
1A
Application procedure-
Registration using OSIRISYes
Aims
Molecular recognition is an essential phenomenon in living systems as well as in artificial ones. It describes the specific interaction between molecules, ranging from discrete complexes to large architectures. The course will discuss supramolecular systems going from basic molecular recognition (involving single, monovalent interactions), to systems with cooperativitye and/or multivalency, and finally to lage polyvalent systems. For all subclasses, molecular and biomolecular examples will be discussed as well as materials applications.
Content
  1. Noncovalent interactions, development of supramolecular chemistry (incl. the Excel modeling of thermodynamec equilibria)
  2. Synthetic host-guest chemistry I: cation-binding hosts
  3. Synthetic host-guest chemistry II: binding of guests in solution
  4. Molecular recognition in biological systems, enzyme catalysis
  5. Sensor concepts and sensor devices
  6. Cooperativity: molecular and biomolecular (e.g. hemoglobin) examples
  7. Multivalency: effective molarity concept, cyclization, cell membrane recognition
  8. Polyvalent systems I: macromolecular assembly + supramolecular polymers
  9. Polyvalent systems II: coordination polymers, MOFs
  10. Polyvalent systems III: proteins an protein folding
  11. Polyvalent systems IV: virus assembly
  12. Polyvalent systems V: DNA + artificial DNA constructs
  13. Polyvalent systems VI: layer-by-layer assembly
  14. Polyvalent systems VII: supramolecular materials
 
Assumed previous knowledge
Mandatory: Organic Chemistry & Thermodynamics
Participating study
Master Chemical Engineering
Participating study
Master Nanotechnology
Required materials
Handouts
Supplementary handouts (review articles, presentation files)
Book
JW Steed & JL Atwood: “Core Concepts in Supramolecular Chemistry and Nanochemistry”, 2007, 1st edition, Wiley, ISBN: 978-0-470-85870-7
Recommended materials
Book
PY Bruice: "Organic Chemistry", 2007, 5th edition, Pearson International Edition/Prentice Hall (or older/newer edition) (chapters/paragraphs on structure of cabohydrates, proteins, and nucleic acids)
Instructional modes
Lecture
Presence dutyYes

Tests
Test 1

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Kies de Nederlandse taal