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Cursus: 193700020
193700020
AMM - Molecular and Biomolecular Chem. and Techn.
Cursus informatieRooster
Cursus193700020
Studiepunten (ECTS)5
CursustypeCursus
VoertaalEngels
Contactpersoonprof.dr.ir. J. Huskens
E-mailj.huskens@utwente.nl
Docenten
Docent
prof.dr. J.J.L.M. Cornelissen
Contactpersoon van de cursus
prof.dr.ir. J. Huskens
Docent
prof.dr.ir. J. Huskens
Collegejaar2020
Aanvangsblok
1A
Aanmeldingsprocedure-
Inschrijven via OSIRISJa
Cursusdoelen
Molecular recognition is an essential phenomenon in living systems as well as in artificial ones. It describes the specific interaction between molecules, ranging from discrete complexes to large architectures. The course will discuss supramolecular systems going from basic molecular recognition (involving single, monovalent interactions), to systems with cooperativitye and/or multivalency, and finally to lage polyvalent systems. For all subclasses, molecular and biomolecular examples will be discussed as well as materials applications.
Inhoud
  1. Noncovalent interactions, development of supramolecular chemistry (incl. the Excel modeling of thermodynamec equilibria)
  2. Synthetic host-guest chemistry I: cation-binding hosts
  3. Synthetic host-guest chemistry II: binding of guests in solution
  4. Molecular recognition in biological systems, enzyme catalysis
  5. Sensor concepts and sensor devices
  6. Cooperativity: molecular and biomolecular (e.g. hemoglobin) examples
  7. Multivalency: effective molarity concept, cyclization, cell membrane recognition
  8. Polyvalent systems I: macromolecular assembly + supramolecular polymers
  9. Polyvalent systems II: coordination polymers, MOFs
  10. Polyvalent systems III: proteins an protein folding
  11. Polyvalent systems IV: virus assembly
  12. Polyvalent systems V: DNA + artificial DNA constructs
  13. Polyvalent systems VI: layer-by-layer assembly
  14. Polyvalent systems VII: supramolecular materials
 
Voorkennis
Verplicht: Organic Chemistry & Thermodynamics
Participating study
Master Chemical Science and Engineering
Participating study
Master Nanotechnology
Verplicht materiaal
Handouts
Supplementary handouts (review articles, presentation files)
Boek
JW Steed & JL Atwood: “Core Concepts in Supramolecular Chemistry and Nanochemistry”, 2007, 1st edition, Wiley, ISBN: 978-0-470-85870-7
Aanbevolen materiaal
Boek
PY Bruice: "Organic Chemistry", 2007, 5th edition, Pearson International Edition/Prentice Hall (or older/newer edition) (chapters/paragraphs on structure of cabohydrates, proteins, and nucleic acids)
Werkvormen
Hoorcollege
AanwezigheidsplichtJa

Toetsen
Tentamen

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