Kies de Nederlandse taal
Course module: 191210720
Biomedical Signal Acquisition
Course info
Course module191210720
Credits (ECTS)5
Course typeCourse
Language of instructionEnglish
Contact persondr. S. Pud
Examiner J.T.W. Berendsen
Contactperson for the course
dr. S. Pud
dr. S. Pud
Academic year2022
Starting block
Application procedureYou apply via OSIRIS Student
Registration using OSIRISYes
To learn and understand about the way relevant biomedical signals from the human body can be measured using chemical and physical sensor systems.

At the end of the course you can:
Learning objectives Way of assessment Level %
explain the major sensor characteristics written exam, review paper knowledge, understanding 15
explain the fundamental operational principles of sensing related to biomedical applications written exam, review paper knowledge, understanding 25
apply the three electrochemical sensing principles in a practical example written exam problem solving 15
explain and critically summarize the operation and characteristics of a set of sensors for a defined biomedical application review paper knowledge, understanding 30
identify the preferred type of sensor for a certain biomedical signal and can mention the do's and don'ts of the first signal processing stage written exam knowledge, understanding 10
acquire sensor signals into a computer and interpret the data w.r.t. a derived model practical work problem solving, practical skills 5
The electrochemical detection methods form a beautiful comprehensive part of this course: starting from electrochemical processes at an electrode and the subsequent mass transport phenomena result in the three basic operational principles (potentiometry, amperometry and conductometry). When the relation between the variable to be determined (ionic species and/or its concentration) and the measured quantity (voltage, current or conductance) is known, the relevant examples follow: the oxygen electrode (Clark electrode), the carbon dioxide sensor (Severinghaus principle) and the pH sensors (glass electrode). Additionally, other chemical biosensors like the glucose sensor, and biosensors based on optical detection principles are treated. The treatment of physical sensor systems is guided by the biomedical application: blood pressure and flow, lung volume and capacity. A bridge to the course Lab-on-a-Chip is formed by some examples of micro Total Analysis Systems, of which the detector is based on one of the mentioned sensor principles.

This course is open for TM, MBE, APH, NANO and EE students. General knowledge from your bachelor programs is required. For TM students, this course bridges the gap between biophysiology and biomedical signal processing and -analysis. This course consists of 12 lectures, where you actively participate in discussions to reach the learning objectives. You will write your critical review paper in teams of two students to train and improve your knowledge and understanding via the original papers you have to review. Moreover, a 4-hr practical project concerning synchronous sensor data retrieval into a computer is one of the instructional modes of this course.

Course Contents
Importance of sensing; Specifications of sensors; Electrode-liquid interface; Electrochemical sensing; potentiometry, amperometry, conductometry; Some other biosensors including optical ones; Electrical signal conditioning with OpAmps; Bioelectricity; Physical sensor principles; Blood flow and pressure sensors; Sensing at the Respiratory System.  

Assessment by a written exam counting for 65 % of the final mark, and writing of a critical review paper (remaining 30%). Both parts must be sufficient ( >= 5,5 ). Remaining 5% for the practical project. Only the failed part has to be redone. As the written exam is an open-book exam, conceptual knowledge and understanding is tested. Notwithstanding, problem solving is part of the questions. Obtainable points per part of every question are indicated on the written exam itself. The written exam consists of several open questions with sub-questions. The review paper is requested to be critical, i.e., it should contain original conclusions based on the reviewed papers, and thus being more than a mere summary of the reviewed papers.
Assumed previous knowledge
one of the technical bachelor programmes
Participating study
Master Biomedical Engineering
Participating study
Master Electrical Engineering
Participating study
Master Technical Medicine
Required materials
Bundled hand-outs and sheets, made available as pdf.
Recommended materials
John G. Webster, Medical Instrumentation, Application and Design, Wiley, ISBN: 978-1-119-45733-6
Instructional modes

Presence dutyYes

Project unsupervised
Presence dutyYes

Self study without assistance

Written exam, Assignments

Kies de Nederlandse taal