Designing biomedical products requires a specific methodical design process, because of the diversity of the stakeholders, the multidisciplinary background of the project participants, the limitation of the amount of background information, the complexity of the working environment in which the products are used and the required safety of the products in combination with a human operator. During this course, a design philosophy/process and accompanying tools are presented, discussed and applied by the students in teams. Illustrative examples will be discussed following the entire design engineering cycle. These include problem analysis, design approach, topology synthesis, system alternatives and improvements, dimensional optimization, choice of components, user input and co-creation, human factors. Topics addressed include prosthetics, orthotics and exoskeletons, minimally access orthopedic surgery, arthroscopy, transmission of forces, static balancing, low-friction mechanisms, medical terminology, human-machine interface, tissue-instrument interface, waterjetting of bone. Students apply the design process by performing by performing a biomedical design project. In addition, the importance of project management, teamwork, communication skills are discussed. Students will apply them to stimulate collaboration between participants of different backgrounds.